• Home
  • Research
    • Neuroblastoma Research >
      • Chromosomal copy number alterations as smoking guns for new therapeutic targets in neuroblastoma
      • Novel combination therapies targeting replication stress resistance and DNA damage repair
      • Targeted protein degradation - PROTAC development
      • ingle-cell and spatial multi-omics mapping of immunomodulatory drug responses
    • PEDIATRIC SARCOMA RESEARCH
    • Patient Avatar Models
  • Publications
  • News
  • People
  • Donate
  • Contact
  • Home
  • Research
    • Neuroblastoma Research >
      • Chromosomal copy number alterations as smoking guns for new therapeutic targets in neuroblastoma
      • Novel combination therapies targeting replication stress resistance and DNA damage repair
      • Targeted protein degradation - PROTAC development
      • ingle-cell and spatial multi-omics mapping of immunomodulatory drug responses
    • PEDIATRIC SARCOMA RESEARCH
    • Patient Avatar Models
  • Publications
  • News
  • People
  • Donate
  • Contact

Neuroblastoma

Picture
Neuroblastoma is a pediatric cancer of the sympathetic nervous system.
It is the most frequent extra-cranial solid childhood tumor, affecting 10-20 children per year in Belgium.

These tumors mostly occur in the adrenal glands in the abdomen and the nervous tissue in the neck, chest, abdomen and pelvis. 

The currently employed intensive multi-modal therapies still achieve disappointingly low perspective for cure, with less than 50% survival rates. In addition, patients that do survive suffer from serious long-term side-effects, including secondary cancer later in life. As such, there is an urgent medical need for more effective and less toxic therapeutic strategies for high-risk neuroblastoma patients, with the integration of precision oncology biomarkers for patient stratification and therapy prediction and monitoring. 


chromosomal COPY number alterations as smoking guns for NEw therapies
Novel combination therapies targeting replication stress resistance and ​Dna damage repair
TARGETED PROTEIN DEGRADATION - ​PROTAC DEvelopment ​
Single-cell and spatial multi-omics to modulate immune responses

Pediatric Precision Oncology Lab Ghent

Understanding childhood cancer
​development for better cures


Donate

Medical Research Building (MRB), 2nd floor
Corneel Heymanslaan 10, B-9000 Ghent, Belgium
​

Tel: +32 9 332 55 33
Email: [email protected]
PPOL lab © 2024
  • Home
  • Research
    • Neuroblastoma Research >
      • Chromosomal copy number alterations as smoking guns for new therapeutic targets in neuroblastoma
      • Novel combination therapies targeting replication stress resistance and DNA damage repair
      • Targeted protein degradation - PROTAC development
      • ingle-cell and spatial multi-omics mapping of immunomodulatory drug responses
    • PEDIATRIC SARCOMA RESEARCH
    • Patient Avatar Models
  • Publications
  • News
  • People
  • Donate
  • Contact