Chromosomal copy number alterations as smoking guns for therapeutic target identification in neuroblastoma

While neuroblastomas present with a low mutational burden, focal and large segmental DNA copy number aberrations are highly recurrent and associated with poor survival. It can be assumed that the affected chromosomal regions contain critical genes implicated in neuroblastoma biology and behavior. More specifically, evidence has emerged that several of these genes are implicated in tumor dependencies thus poten-
tially providing novel therapeutic entry points.