Chromosomal copy number alterations as smoking guns for new therapeutic targets in neuroblastoma

While neuroblastomas present with a low mutational burden, focal and large segmental DNA copy number aberrations are highly recurrent and associated with poor survival. It can be assumed that the affected chromosomal regions contain critical genes implicated in neuroblastoma biology and behavior. More specifically, evidence has emerged that several of these genes are crucial tumor dependencies thus potentially providing novel therapeutic entry points.